Record Display for the EPA National Library Catalog

RECORD NUMBER: 10 OF 11

OLS Field Name OLS Field Data
Main Title Species Susceptibility to Delayed Toxic Neuropathy in Relation to In vivo Inhibition of Neurotoxic Esterase by Neurotoxic Organophosphorus Esters.
Author Soliman, Salah A. ; Linder, Ralph ; Farmer, Jackie ; Curley, August ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-238;
Stock Number PB82-249319
Additional Subjects Esterase ; Esters ; Laboratory animals ; Inhibition ; Tolerances(Physiology) ; Chickens ; Mice ; Phosphorus organic compounds ; Esters ; Reprints ; Phosphoric acid/(tricresyl-ester) ; Neurotoxins ; Phosphonothioic acid/ethyl-(cyanophenyl)-phenyl
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-249319 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract
Tri-o-cresyl phosphate (TOCP) and O-ethyl O-(4-cyanophenyl) phenylphosphonothioate (cyanofenphos, Surecide) were found to be delayed neurotoxicants. The results suggest that the differences between chickens and mice in susceptibility to neurotoxic organophosphates may be attributed to (1) inhibitor specificity of NTE forms in the brain in these two different animal species and/or (2) inability of the active metabolites of these neurotoxic compounds to reach the site of action.