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RECORD NUMBER: 2 OF 3

OLS Field Name OLS Field Data
Main Title Chemical Reactivity, Cytotoxicity, and Mutagenicity of Chloropropanones.
Author Merrick, B. A. ; Smallwood, C. L. ; Meier, J. R. ; McKean, D. L. ; Kaylor, W. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/277;
Stock Number PB88-185525
Additional Subjects Chemical reactions ; Toxicity ; Chlorine organic compounds ; Rats ; Water treatment ; Laboratory animals ; In vitro analysis ; Cytology ; Disinfection ; Mutagens ; Carcinogens ; Chlorination ; Disinfection ; Salmonella ; Biodeterioration ; Humans ; Exposure ; Concentration(Composition) ; pH ; Metabolism ; Reprints ; Chloropropanones ; Haloketones ; Propanone/dichloro ; Propanone/monochloro
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NTIS  PB88-185525 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 11p
Abstract
Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP) and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic to suspensions of male, rat hepatocytes in a concentration range of 0.5-10 mM. Cytotoxicity was preceded by rapid decline in cellular GSH levels. Mutagenic potencies among the chloropropanes in Salmonella typhimurium bacteria differed greatly. 1,3-DCP was mutagenic in the nmole range, 1,1-DCP was weakly mutagenic in the micromole range and MCP was not mutagenic. Mutagenicity of the dichloropropanones was evident without metabolic activation.