||Initiation, Promotion, and Complete Carcinogenesis by N-Methyl-N'-Nitro-N-Nitrosoguanidine or Ethylnitrosourea in the SENCAR Mouse Skin Tumorigenesis Model.
O'Connell, J. F. ;
Nesnow, S. ;
Slaga, T. J. ;
||Health Effects Research Lab., Research Triangle Park, NC.;Texas Univ. System Cancer Center, Smithville.
Nitro compounds ;
Skin cancer ;
Skin neoplasms ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Five doses of either N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 micromol. As complete carcinogens, MNNG from doses of 0.5-5.0 micromol and ENU from doses of 10 micromol-40 micromol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)