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RECORD NUMBER: 8 OF 9

OLS Field Name OLS Field Data
Main Title Selection of Candidate Compounds for In vitro Teratogenesis Test Validation.
Author Smith, M. K. ; Kimmel, G. L. ; Kochhar, D. M. ; Shepard, T. H. ; Spielberg, S. P. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Hospital for Sick Children, Toronto (Ontario). ;Jefferson Medical Coll., Philadelphia, PA. ;National Center for Toxicological Research, Jefferson, AR. ;Washington Univ., Seattle. School of Medicine.
Year Published 1983
Report Number EPA/600/J-83/241;
Stock Number PB84-245562
Additional Subjects Toxicology ; In vitro analysis ; Validation ; Tests ; In vivo analysis ; Reprints ; Teratogenesis
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-245562 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 22p
Abstract
The Consensus Workshop on In Vitro Teratogenesis Testing recommended that test validation be facilitated by a listing of agents with defined teratogenicity; subsequently, a panel was convened to review and select such agents. This communication establishes a list of 47 compounds or conditions which demonstrate a wide range of teratogenicity in vivo. The agents were chosen primarily on the strength of the literature base denoting their in vivo effects. The tables note a number of general biological and toxicological characteristics for each agent, and the details of representative in vivo teratology studies are summarized and referenced. This list is intended to serve as a base for in vitro teratogenesis test validation and should prove useful in developing and identifying those systems which will contribute to a more effective testing program.