||Selection of Candidate Compounds for In vitro Teratogenesis Test Validation.
Smith, M. K. ;
Kimmel, G. L. ;
Kochhar, D. M. ;
Shepard, T. H. ;
Spielberg, S. P. ;
||Health Effects Research Lab., Cincinnati, OH. ;Hospital for Sick Children, Toronto (Ontario). ;Jefferson Medical Coll., Philadelphia, PA. ;National Center for Toxicological Research, Jefferson, AR. ;Washington Univ., Seattle. School of Medicine.
In vitro analysis ;
In vivo analysis ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The Consensus Workshop on In Vitro Teratogenesis Testing recommended that test validation be facilitated by a listing of agents with defined teratogenicity; subsequently, a panel was convened to review and select such agents. This communication establishes a list of 47 compounds or conditions which demonstrate a wide range of teratogenicity in vivo. The agents were chosen primarily on the strength of the literature base denoting their in vivo effects. The tables note a number of general biological and toxicological characteristics for each agent, and the details of representative in vivo teratology studies are summarized and referenced. This list is intended to serve as a base for in vitro teratogenesis test validation and should prove useful in developing and identifying those systems which will contribute to a more effective testing program.