Includes bibliographies and index.

Response to physical agents -- Effects of noise exposure on auditory sensitivity -- Pathophysiological responses of the auditory organ to excessive sound -- Extraauditory effects of acoustic stimulation -- Heat -- Control of body temperature -- Heat exchange between human skin surface and thermal environment -- Human tolerance to hot climates -- Microwaves -- Microwave radiation -- Ionizing radiation -- Effects of ionizing radiation on mammalian cells -- Nature, origin, and distribution of chemical agents -- Chemical agents in air -- Food additives and contaminants -- Chemical agents from occupational sources -- Medicines and drugs as environmental agents -- Chemical agents in cigarette smoke -- Reactions and determinants at portal of entry -- Respiratory system -- Regional deposition of particles in the human respiratory tract -- Radioactive materials: determinants of dose to the respiratory tract -- Clearance mechanisms in the respiratory tract -- Tissue and cellular reactions to particles, fibers, and aerosols retained after inhalation -- Immunological reactions to inhaled physical and chemical agents -- Skin -- Permeability of the skin -- Cutaneous allergic response -- Cutaneous carcinogenesis: metabolic interaction of chemical carcinogens with skin -- Alimentary system -- Gastroenterologic response to environmental agents: absorption and interactions -- Metabolism of foreign substances in the gastrointestinal tract -- Retention and excretion kinetics of chemical agents -- Transportation and transformation of chemical agents -- Determinants of xenobiotic transport at biological barriers -- Hepatic and extrahepatic mixed- function oxidases -- Hydrolytic transformation of environmental pollutants -- Biochemistry and significance of transferase reactions in the metabolism of foreign chemicals -- Distribution and excretion of chemical agents and derivatives -- Storage and release -- Bone storage and release -- Accumulation and release of chemicals by adipose tissue -- Renal excretion -- Mechanisms of renal excretion of environmental agents -- Renal injury and urinary excretion -- Alimentary excretion of environmental agents and unnatural compounds -- Biliary excretion -- Pulmonary excretion of absorbed gases -- Mechanism of cellular injury -- Altered permeability of cell membranes -- Formation of reactive metabolites of foreign compounds and their covalent binding to cellular constituents -- Lipid peroxidation: a specific form of cellular injury -- Intracellular digestion: lysosomes and cellular injury -- Action of environmental agents on nucleic acids and their metabolism -- Altered protein synthesis.