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RECORD NUMBER: 25 OF 27

OLS Field Name OLS Field Data
Main Title Pulmonary Effects Due to Short-Term Exposure to Oil Fog.
Author Selgrade, M. K. ; Hatch, G. E. ; Grose, E. C. ; Illing, J. W. ; Snead, A. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;Experimental Pathology Associates, Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/094;
Stock Number PB88-139639
Additional Subjects Toxicology ; Respiratory system ; Exposure ; Rats ; Laboratory animals ; Vaporization ; Histopathology ; Reprints ; Air pollution effects ; Oil fog
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-139639 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 15p
Abstract
Rats were exposed to an oil fog generated by flash vaporization and subsequent condensation of light weight lubricating oil. Exposures were for 3.5 hrs/day, 4 days/wk, for 4 wks, at concentrations of 1.5, 0.5, or 0.1mg/1 and a particle size of approximately 1 micronole. Samples of respiratory tissues were taken for histopathologic analyses, lavage fluid samples were collected, and pulmonary function measurements were made the day after the last exposure. An accumulation of macrophages within the alveolar lumen, an increase in lavage fluid protein content, and an increase in total cell content in lavage fluid due to an influx of polymorphonuclear leukocytes was noted in rats exposed at the 1.5 mg level. Also, for the exposure group there was an increase in lung wet and dry weight, and an increase in end expiratory volume, and pneumonitis was observed histopathologically in 4 of 10 male rats exposed. Pneumonitis was not observed among 6 female rats examined. Oil fog had no effect on total lung capacity, residual volume, vital capacity, lung compliance, or the distribution of ventilated air within the lung. Effects following exposure to 0.5 mg/1 were limited to slight accumulation of macrophages in the alveolar lumen and an increase in the total cells in lavage fluid which could not be attributed to an increase in any particular cell type.