Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 10

OLS Field Name OLS Field Data
Main Title Fetal Dexamethasone Exposure Accelerates Development of Renal Function: Relationship to Dose, Cell Differentiation and Growth Inhibition.
Author Slotkin, T. A. ; Seidler, F. J. ; Kavlock, R. J. ; Gray., J. A. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA-R-813769; EPA/600/J-94/216;
Stock Number PB94-163953
Additional Subjects Dexamethasone ; Kidney ; Cell differentiation ; Fetal growth retardation ; Pharmacology ; Dose-response relationships ; Glucocorticoids ; Urinalysis ; Sodium ; Potassium ; Urea ; Water ; Fetus ; Rats ; Organ weight ; Glomerular filtration rate ; Reprint ; Health effects ; Tubular function
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB94-163953 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 9p
Abstract
Fetal exposure to high doses of glucocorticoids slows cellular development and impairs organ performance, in association with growth retardation. Nevertheless, low doses of glucocorticoids may enhance cell differentiation and accelerate specific functions. The current study examined this apparent paradox in the developing rat kidney, using doses of dexamethasone that span the threshold for growth impairment: 0.05 or 0.2 mg/kg given on gestational days 17, 18 and 19. At the lower dose, which did not significantly retard body growth, the postnatal development of tubular reabsorptive capabilities for sodium, potassium, osmotic particles, water and urea was accelerated. These effects were less notable at the higher dose, which caused initial body growth impairment. (Copyright (c) Caxton Communications Limited.)