Record Display for the EPA National Library Catalog

RECORD NUMBER: 18 OF 19

OLS Field Name OLS Field Data
Main Title Toxicity of Guthion (Trade Name) and Guthion (Trade Name) 2S to 'Xenopus laevis' Embryos.
Author Schuytema, G. S. ; Nebeker, A. V. ; Griffis, W. L. ;
CORP Author Corvallis Environmental Research Lab., OR.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/367;
Stock Number PB94-209731
Additional Subjects Toxicity ; Water pollution effects(Animals) ; Frogs ; Pesticides ; Amphibia ; Embryos ; Teratogens ; Assaying ; Dose-response relationships ; Mortality ; Abnormalities ; Lethal dosage ; Reprints ; Guthion(Trademark) ; Xenopus laevis ; FETAX(Frog Embryo Teratogenesis Assay-Xenopus)
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NTIS  PB94-209731 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/11/1994
Collation 6p
Abstract
Differences in sensitivity to waterborne contaminants between wildlife species have prompted investigations on the sensitivity of amphibiams to potentially hazardous environmental chemicals. The development of Xenopus laevis (African clawed frog) embryos exposed to the pesticide Guthion(Trademark) (technical grade) and Guthion(Trademark) 2S (commercial formulation) was evaluated in modified Frog Embryo Teratogenesis Assay--Xenopus (FETAX) tests. The embryos were exposed to five or six increasing concentrations of pesticide in 10- and 100-ml exposure volumes of test solution for 96 h. Embryos exposed to 10-ml volumes of Guthion exhibited increased mortality, increased deformation, and decreased size as compared to those exposed in 100-ml volumes. LC50s for embryos exposed in the 10-ml Guthion tests ranged from 6.1 to 6.3 mg/L as compared to 10.6 to 11.9 mg/L for those in the 100-ml tests.