||Substituent Contribution to the Partition Coefficients of Substituted Benzenes in Solvent-Water Mixtures.
Chiou, Cary T. ;
Schmedding, David W. ;
Block, John H. ;
Manes, Milton ;
||Oregon State Univ., Corvallis. Environmental Health Sciences Center. ;Kent State Univ., OH. Dept. of Chemistry.;Corvallis Environmental Research Lab., OR.
Organic compounds ;
Physicochemical properties ;
Partition coefficients ;
Biological processes ;
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In the course of correlation analysis for biological activities, octanol-water partition coefficients (P) have been used widely to express the lipophilic interactions of organic compounds with biological substrates. Since discrepancies are found between some pi values from different parent compounds and these variations depend also on the nature of the solvent-water system being used, it is of interest to examine the relationship between and pertinent physicochemical properties to identify the factors that account for the discrepancies.