||Comparison of Chronic and Acute Low-Level Exposure Effects of Carbaryl on the EEG of Squirrel Monkeys.
Santolucito., J. A. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Experimental data ;
Parenteral infusions ;
Laboratory animals ;
Central nervous system ;
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The purpose of the present experiment was to compare the effects on the anesthetized electroencephalogram (EEG) of low-level, chronic carbaryl feeding with those resulting from a single i.v. injection in Squirrel monkeys. Six chronic monkeys have received 0.007 mg/kg carbaryl per day in a miniature marshmallow for 26 months. Their EEG's were compared to those of 6 contemporary control animals receiving a daily marshmallow without pesticide. Acutely dosed monkeys were intravenously given 6 mg/kg carbaryl in 0.15 ml 95% ethanol. Their pre- and post-injection EEGs were compared. It is concluded that low-level chronic exposure of Squirrel monkeys to carbaryl results in detectable changes in the anesthetized EEG patern and that several but not all of these changes are seen in acutely dosed monkeys.