||Observations on the Alteration by Carbaryl of Smooth Muscle Preparation Responses to Norepinephrine.
Santolucito, J. A. ;
Hassan, A. ;
Whitcomb., E. R. ;
||Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Experimental data ;
Laboratory animals ;
Autonomic nervous system ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The present experiment was an attempt to determine whether carbaryl interacts directly with adrenergic mechanisms. Motility response patterns to norepinephrine (NE) in conjunction with alpha- and beta-receptor blocking agents were recorded from isolated preparations of uteri from ovariectomized rats and intestinal segments from rats and rabbits. It is concluded that carbaryl can interact with adrenergic receptors behaving as a beta-sympathomimetic in uterine preparations and as an alpha-blocking agent in intertinal segments.