Record Display for the EPA National Library Catalog

RECORD NUMBER: 145 OF 206

Main Title Polyploidization and Cancer [electronic resource] /
Type EBOOK
Author Poon, Randy Y. C.
Publisher Springer New York,
Year Published 2010
Call Number R-RZ
ISBN 9781441961990
Subjects Medicine
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-1-4419-6199-0
Collation XV, 151 p. online resource.
Notes
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Polyploidy, Aneuploidy and the Evolution of Cancer -- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability -- Understanding Cytokinesis Failure -- DNA Damage and Polyploidization -- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization -- Centrosomes, Polyploidy and Cancer -- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells -- Polyploidization of liver cells -- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry. Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.