||Correlation between Chemical Suppression of Natural Killer Cell Activity in Mice and Susceptibility to Cytomegalovirus: Rationale for Applying Murine Cytomegalovirus as a Host Resistance Model and for Interpreting Immunotoxicity Testing in Terms of Risk of Disease.
Selgrade, M. K. ;
Daniels, M. J. ;
Dean, J. H. ;
||Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Sterling Research Group, Rensselaer, NY. Drug Safety Assessment.
Natural killer cells ;
Cytomegalic inclusion disease ;
Immunosuppressive agents ;
In vivo analysis ;
Biological models ;
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The purpose of the study was to determine the relationship between chemical suppression of natural killer (NK) cell activity in mice and chemical effects on susceptibility to murine cytomegalovirus (MCMV) infection. Data from studies with 8 chemicals administered in various doses and by various routes were evaluated, and a statistically significant correlation was observed between chemical suppression of virus-augmented NK cell activity and increased mortality due to MCMV infection. In contrast, effects of the same chemical treatments on spontaneous NK cell activity (i.e., NK cell activity in uninfected mice) did not correlate with effects of these chemicals on mortality due to MCMV.