Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title CASE: The Computer-Automated Structure Evaluation System, as an Alternative to Extensive Animal Testing.
Author Rosenkranz, H. S. ; Klopman, G. ;
CORP Author Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Cincinnati, OH.
Publisher c1988
Year Published 1988
Report Number EPA-R-812264; EPA/600/J-88/407;
Stock Number PB90-111550
Additional Subjects Toxicology ; Substitutes ; Diagnostic routines ; Reprints ; Computer automated structure evaluation(CASE) ; Carcinogenicity tests ; Animal testing alternatives ; Computer applications ; Structure-activity relationship
Library Call Number Additional Info Location Last
NTIS  PB90-111550 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/1990
Collation 10p
CASE, an artificial intelligence system with demonstrated ability to predict biological activity based on structural considerations, correctly predicts animal carcinogenicity. It can, therefore, play a pivotal role in classifying chemicals as carcinogens and prioritizing them for further testing. Additionally, CASE shows promise in the design of pharmacologically active agents by reducing the number of drugs that need to be synthesized and tested. For both of these applications, CASE provides a mechanism to conserve animal and other testing resources.