||Carcinogenic N-Hydroxylaminopurine Derivatives Do Not Act as Base Analog Mutagens in 'Salmonella typhimurium'.
McCartney, M. ;
McCoy, E. C. ;
Rosenkranz, H. S. ;
Giner-Sorolla, A. ;
||Case Western Reserve Univ., Cleveland, OH. ;University of South Florida, Tampa. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Salmonella typhimurium ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
N-hydroxylaminopurines are highly mutagenic for growing as well as resting Salmonella typhimurium strain TA100 and to a lesser extent for strain TA98. Aminopurines, under similar conditions, are not mutagenic. N-methylhydroxylaminopurine, under similar conditions, exhibits only minimal activity. The results are taken to indicate that unlike non-hydroxylated aminopurines, N-hydroxylaminopurines exert their mutagenicity not by acting as base analogs but by direct covalent binding with DNA-guanine.