Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 21

OLS Field Name OLS Field Data
Main Title Carcinogenic N-Hydroxylaminopurine Derivatives Do Not Act as Base Analog Mutagens in 'Salmonella typhimurium'.
Author McCartney, M. ; McCoy, E. C. ; Rosenkranz, H. S. ; Giner-Sorolla, A. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. ;University of South Florida, Tampa. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-809231; EPA/600/J-85/367;
Stock Number PB86-188216
Additional Subjects Bacteria ; Toxicology ; Mutagens ; Reprints ; Carcinogenesis ; Salmonella typhimurium ; Aminopurine/hydroxyl
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-188216 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 10p
Abstract
N-hydroxylaminopurines are highly mutagenic for growing as well as resting Salmonella typhimurium strain TA100 and to a lesser extent for strain TA98. Aminopurines, under similar conditions, are not mutagenic. N-methylhydroxylaminopurine, under similar conditions, exhibits only minimal activity. The results are taken to indicate that unlike non-hydroxylated aminopurines, N-hydroxylaminopurines exert their mutagenicity not by acting as base analogs but by direct covalent binding with DNA-guanine.