Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 21

OLS Field Name OLS Field Data
Main Title Esterification of Arylhydroxylamines: Evidence for a Specific Gene Product in Mutagenesis.
Author McCoy, E. C. ; McCoy, G. D. ; Rosenkranz, H. S. ;
CORP Author Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA/600/J-82/459;
Stock Number PB86-185170
Additional Subjects Toxicology ; Bacteria ; Polycyclic aromatic hydrocarbons ; Reprints ; Mutagenesis ; Nitroarenes ; Salmonella typhimurium
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB86-185170 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 9p
Abstract
Characterization of a Salmonella typhimurium mutant strain (TA98/1,8-DNP6) resistant to the mutagenicity of nitrated polycyclic aromatic hydrocarbons (nitroarenes) revealed that it was also non-responsive to the mutagenic action of nitroso- and N-hydroxylaminoarenes. The mutant strain was fully sensitive to the mutagenic action of the corresponding hydroxamic acid ester. These results suggest that TA98/1,8-DNP6 is deficient in a specific esterifying enzyme and that esterification of the penultimate mutagenic metabolites of nitro- and aminoarenes (e.g., arylhydroxylamines) to form potent electrophiles is controlled by a specific gene.