||Esterification of Arylhydroxylamines: Evidence for a Specific Gene Product in Mutagenesis.
McCoy, E. C. ;
McCoy, G. D. ;
Rosenkranz, H. S. ;
||Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Polycyclic aromatic hydrocarbons ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Characterization of a Salmonella typhimurium mutant strain (TA98/1,8-DNP6) resistant to the mutagenicity of nitrated polycyclic aromatic hydrocarbons (nitroarenes) revealed that it was also non-responsive to the mutagenic action of nitroso- and N-hydroxylaminoarenes. The mutant strain was fully sensitive to the mutagenic action of the corresponding hydroxamic acid ester. These results suggest that TA98/1,8-DNP6 is deficient in a specific esterifying enzyme and that esterification of the penultimate mutagenic metabolites of nitro- and aminoarenes (e.g., arylhydroxylamines) to form potent electrophiles is controlled by a specific gene.