Main Title |
Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised). |
Author |
Taubeneck, M. W. ;
Daston, G. P. ;
Rogers, J. M. ;
Keen, C. L. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC. |
Publisher |
c1994 |
Year Published |
1994 |
Report Number |
EPA/600/J-94/400; NIH-HD01743; |
Stock Number |
PB95-126447 |
Additional Subjects |
Zinc ;
Metabolism ;
Toxicity ;
Rats ;
Maternal exposure ;
Nutrition ;
Biological effects ;
Maternal-fetal exchange ;
Dose-response relationships ;
Food consumption ;
Statistical analysis ;
Urethane ;
Arsenic ;
Alcohols ;
Melphalan ;
Metallothionein ;
Reprints ;
Alpha-hederin ;
Acute phase response
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB95-126447 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development. |