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RECORD NUMBER: 30 OF 62

OLS Field Name OLS Field Data
Main Title Immune Function in Mice Exposed to the Adenosine Deaminase Inhibitor 2'-Deoxycoformycin During Immune System Development.
Author Luebke, R. W. ; Lawson, L. D. ; Rogers, R. R. ; Riddle, M. M. ; Smialowicz, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/245;
Stock Number PB88-177134
Additional Subjects Immunity ; Mice ; Exposure ; Laboratory animals ; Inhibitors ; Reprints ; Adenosine deaminase ; Deoxycoformycin
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB88-177134 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 15p
Abstract
Pregnant mice were administered 2'-deoxycoformycin (2dCF), a potent inhibitor of adensoine deaminase activity, by intraperitoneal injection on day 7 or 15 of gestation or from day 8-12 or 14-18 of gestation. A total dose of 0, 0.5 or 2.0 micrograms 2dCF/g of maternal body weight was given to all dams. In a separate study, pups born to nontreated dams were given 5 intraperitoneal injections totaling 0, 0.5, 2.0 or 4.0 micrograms 2dCF/g beginning at 4 weeks of age. Administered doses of 2dCF were at levels known to profoundly suppress adenosine deaminase levels in adult mice. Pups born to dams injected with 2dCF from day 14-18 all died within 48 h of birth whereas other injection schedules had no effect on birth rate or survival of pups. In utero 2dCF exposure had little effect on immune function in offspring. On the other hand, body, spleen and thymus weight, and splenic cellularity were decreased in weanling mice 24 h after the last injection of 4 micrograms/g 2dCF. Proliferative responses of splenocytes to T cell mitogens and alloantigens were likewise suppressed at both 2.0 and 4.0 micrograms/g 2dCF.