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RECORD NUMBER: 14 OF 62

OLS Field Name OLS Field Data
Main Title Effects of Manganese, Calcium, Magnesium, and Zinc on Nickel-Induced Suppression of Murine Natural Killer Cell Activity.
Author Smialowicz, R. J. ; Rogers, R. R. ; Riddle, M. M. ; Luebke, R. W. ; Fogelson, L. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/031;
Stock Number PB87-198404
Additional Subjects Toxicity ; Chemical Compounds ; Nickel ; Carcinogens ; Mice ; Magnesium ; Manganese ; Calcium ; Zinc ; NK cells ; Natural killer cells ; Antagonists and inhibitors
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB87-198404 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 16p
Abstract
The effects that divalent metals have on nickel-induced suppression of natural killer (NK) cell activity were studied in mice. Male CBA/J mice were given a single intramuscular injection of nickel chloride (4.5-36 micrograms NiCl2/g), manganese chloride (20-80 micrograms MnCl2/g), magnesium acetate (50-200 micrograms MgOAc/g), zinc acetate (208 micrograms AnOAc/g) or calcium acetate (12.5-50 micrograms CaOAc/g), and splenic NK cell activity was assessed 24 hours later using a (51)Cr release assay. The data indicate that both the divalent metal and the timing of its injection relative to Ni injection are critical for altering Ni-induced suppression of NK cell activity. (Copyright (c) 1987 by Hemisphere Publishing Corporation.)