Record Display for the EPA National Library Catalog

RECORD NUMBER: 21 OF 31

OLS Field Name OLS Field Data
Main Title Perinatal Toxicity of Endrin in Rodents. II. Fetotoxic Effects of Prenatal Exposure in Rats and Mice.
Author Kavlock, Robert J. ; Chernoff, Neil ; Hanisch, Roert C. ; Gray, Jacqueline ; Rogers, Ellen ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-140;
Stock Number PB82-247248
Additional Subjects Toxicology ; Endrin ; Pesticides ; Rats ; Mice ; Laboratory animals ; Ingestion(Biology) ; Dosage ; Sensitivity ; Reprints ; Fetuses ; Dimethanonaphthalenes
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-247248 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 12p
Abstract
The fetotoxic potential of endrin in the CD rat and CD-1 mouse was investigated. Endrin was administered as a solution in corn oil to groups of pregnant animals by gastric intubation at multiple dose levels throughout the period of organogenesis. The data suggest that species differences in sensitivity to endrin may in part be due to differences in metabolism. Although endrin levels in rat fetuses at a maximally tolerated dosage level resembled those previously reported for the hamster, relatively less 12-ketoendrin was present, paralleling the change in fetal sensitivity.