||Perinatal Toxicity of Endrin in Rodents. II. Fetotoxic Effects of Prenatal Exposure in Rats and Mice.
Kavlock, Robert J. ;
Chernoff, Neil ;
Hanisch, Roert C. ;
Gray, Jacqueline ;
Rogers, Ellen ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
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The fetotoxic potential of endrin in the CD rat and CD-1 mouse was investigated. Endrin was administered as a solution in corn oil to groups of pregnant animals by gastric intubation at multiple dose levels throughout the period of organogenesis. The data suggest that species differences in sensitivity to endrin may in part be due to differences in metabolism. Although endrin levels in rat fetuses at a maximally tolerated dosage level resembled those previously reported for the hamster, relatively less 12-ketoendrin was present, paralleling the change in fetal sensitivity.