Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Subacute and Subchronic Oral Toxicity of 1,3-Dichloropropane in the Rat.
Author Terrill, J. B. ; Robinson, M. ; Wolfe, G. W. ; Billups., L. H. ;
CORP Author Hazleton Labs. America, Inc., Rockville, MD.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA-68-03-4008; EPA/600/J-92/121;
Stock Number PB92-164912
Additional Subjects Toxicity ; Kidney ; Rats ; Food consumption ; Body weight ; Dose-response relationships ; Hematology ; Pathology ; Organ weight ; Blood chemical analysis ; Males ; Females ; Reprints ; Dichloropropanes
Library Call Number Additional Info Location Last
NTIS  PB92-164912 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/22/1992
Collation 12p
1,3-Dichloropropane (DCP) was administered by gavage for 14 and 90 days to male and female Sprague-Dawley-derived rats (10/sex/group). Evaluations included body weight, food consumption, clinical signs, hematology, clinical chemistry, organ weights. and gross and microscopic pathology. In the 14-day study using levels of 200, 600 and 1800 mg/kg/day, all high-dose group animals died while none died in the other two treatment groups. Other signs associated with treatment in high-dose animals included languid behavior, salivation (also seen in mid-dose group animals), dyspnea and prostration. No differences were found between animals in the low or mid-dose groups compared to the control animals for body weight, food consumption, hematology, gross postmortem and histopathology data. Total protein and albumin blood levels were increased for low- and mid-dose females, and mid-dose females, respectively. The clinical chemistry findings appeared to be treatment-related as they were accompanied by significantly increased liver (absolute and relative: both sexes of mid-dose animals) and kidney weights (absolute and relative: mid-dose males).