1,3-Dichloropropane (DCP) was administered by gavage for 14 and 90 days to male and female Sprague-Dawley-derived rats (10/sex/group). Evaluations included body weight, food consumption, clinical signs, hematology, clinical chemistry, organ weights. and gross and microscopic pathology. In the 14-day study using levels of 200, 600 and 1800 mg/kg/day, all high-dose group animals died while none died in the other two treatment groups. Other signs associated with treatment in high-dose animals included languid behavior, salivation (also seen in mid-dose group animals), dyspnea and prostration. No differences were found between animals in the low or mid-dose groups compared to the control animals for body weight, food consumption, hematology, gross postmortem and histopathology data. Total protein and albumin blood levels were increased for low- and mid-dose females, and mid-dose females, respectively. The clinical chemistry findings appeared to be treatment-related as they were accompanied by significantly increased liver (absolute and relative: both sexes of mid-dose animals) and kidney weights (absolute and relative: mid-dose males).