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RECORD NUMBER: 37 OF 52

OLS Field Name OLS Field Data
Main Title Ninety-Day Toxicity Study of Chloral Hydrate in the Sprague-Dawley Rat.
Author Daniel, F. B. ; Robinson, M. ; Stober, J. A. ; Page, N. P. ; Olson, G. R. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Page Associates, Gaithersburg, MD. ;Pathology Associates, Inc., West Chester, OH.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/366;
Stock Number PB93-107118
Additional Subjects Toxicity ; Chloral hydrate ; Lactate dehydrogenase ; Food consumption ; Water consumption ; Body weight ; Dose-response relationships ; Necrosis ; Liver ; Alanine aminotransferase ; Aspartate aminotransferase ; Males ; Females ; Organ weight ;
Holdings
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Status
NTIS  PB93-107118 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1993
Collation 18p
Abstract
Male and female Sprague-Dawley rats were administered drinking water containing 300, 600, 1200, or 2400 mg/L chloral hydrate for 90 days. A Control group received distilled water only. No animals died during the study and no differences were observed in body weight gain or food and water consumption, except for males at the highest-dose level. Minor treatment-related effects were observed for organ weights and hematological parameters and these did not appear to be of toxicological significance. Some indications of toxicity were evident in the 2400 mg/L male group (equivalent to 168 mg/kg-day) including a significant decrease in food and water consumption and in weight gain. In addition, histopathological examination of these animals revealed an apparent increase in the incidence of focal hepatocellular necrosis. Increases in AST, ALT and LDH, which occurred at several dose levels in males, but particularly at 2400 mg/L, are consistent with the hepatocellular necrosis of minimal to mild severity diagnosed by microscopic examination. These liver changes, except for sporadic enzyme changes, were not seen in the female rats which actually consumed higher doses of chloral hydrate (e.g. 288 mg/kg-day at 2400 mg/L). (Copyright (c) 1992 by Marcel Dekker, Inc.)