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RECORD NUMBER: 34 OF 40

OLS Field Name OLS Field Data
Main Title Methoxyacetaldehyde, an Intermediate Metabolite of 2-Methoxyethanol, Is Immunosuppressive in the Rat.
Author Smialowicz, R. J. ; Riddle, M. M. ; Williams, W. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher 1993
Year Published 1993
Report Number EPA/600/J-94/037;
Stock Number PB94-137171
Additional Subjects Immunosuppressive agents ; Metabolism ; Rats ; Disulfiram ; Cyanamide ; Aldehyde dehydrogenase ; Reprints ; Acetaldehyde/methoxy ; Ethanol/2-methoxy
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB94-137171 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/14/1994
Collation 7p
Abstract
2-Methoxyethanol (ME) is metabolized to 2-methoxyacetic acid (MAA) via the intermediate metabolite methoxyacetaldehyde (MAAD). In this study, the plaque-forming cell (PFC) response to trinitrophenyl-lipopolysaccharide (TNP-LPS) was used to determine if MAAD is immunosuppressive in rats. Rats pretreated with the aldehyde dehydrogenase inhibitors disulfiram or cyanamide followed by oral dosing with ME resulted in suppressed PFC responses equivalent to the suppressed responses of rats dosed with ME alone. Rats pretreated with disulfiram and then dosed with 2.64 mmol/kg 2-methoxyethyl acetate (MEA), also resulted in suppressed PFC responses similar to that of MEA alone. In contrast, coadministration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA blocked suppression of the PFC response following exposure to ME or MEA alone. Oral dosing with equimolar concentrations of ME, MAA, or MAAD resulted in equivalent suppression of the TNP-LPS PFC response. Rats exposed to either disulfiram or cyanamide and MAAD also resulted in suppression of the PFC response.