Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Enhancement of Natural Killer Cell Activity and Interferon Production by Manganese in Young Mice.
Author Smialowicz, R. J. ; Riddle, M. M. ; Rogers, R. R. ; Luebke, R. W. ; Burleson, G. R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/J-88/019;
Stock Number PB88-219738
Additional Subjects Mice ; Laboratory animals ; Manganese ; Immunity ; Reprints ; Natural killer cell ; Activity(Biology) ; Manganese chloride ; Immunotoxicity
Library Call Number Additional Info Location Last
NTIS  PB88-219738 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/29/1988
Collation 17p
The effect that MnCl2 has on murine splenic natural killer (NK) cell activity was investigated in infant (10 days old), pre-weanling (18 days old) and weanling (24 days old) C57BL/6J mice. Both MnCl2 and Poly I:C caused elevations in serum interferon levels. Time-course studies revealed that interferon levels returned to normal within 48 hours following injection with either MnCl2 or Poly I:C; however enhanced NK activity persisted for up to 48 hours in Poly I:C-injected mice and 72 hours in MnCl2-injected mice. These results indicate that despite low levels of NK activity in pre-weanling mice, MnCl2 is capable of enhancing this activity by 8-9 fold. Furthermore, Mn-enhanced NK activity in these young mice appears to be mediated by the production of interferon alpha, beta.