Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Enhancement of Experimental Respiratory Infection following Nickel Inhalation.
Author Adkins, Jr., B. ; Richards, J. H. ; Gardner, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1979
Report Number EPA-600/J-79-150;
Stock Number PB83-193490
Additional Subjects Respiratory diseases ; Nickel chloride ; Respiration ; Streptococcal infections ; Mortality ; Responses ; Reprints ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB83-193490 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 13p
The effects of nickel chloride inhalation on the enhancement of experimentally induced streptococcal infections were studied. Exposure to nickel chloride for 2 hr produced significant enhancement in mortality. This response was observed for 24 hr after the nickel chloride exposure. A delayed clearance response of inhaled streptococci, also observed in the nickel-treated mice, supported the mortality data. Several parameters involving pulmonary cells obtained by in situ lavage 24 hr after nickel chloride exposure were also studied; no reduction in total cell yield, viability, or cellular composition was observed. A significant reduction in phagocytic capability, as compared to that of control animal cells, was observed in alveolar macrophages obtained 24 hr after nickel chloride exposure.