Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Comparative Hepatotoxicity of Inhaled Cadmium Chloride and Cadmium Oxide (Journal Version).
Author Grose, E. C. ; Richards, J. H. ; Jaskot, R. H. ; Menache, M. G. ; Graham, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;North Carolina State Univ., Raleigh.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/426;
Stock Number PB89-109854
Additional Subjects Toxicity ; Cadmium inorganic compounds ; Liver ; Respiration ; Laboratory animals ; Exposure ; Aerosols ; Enzymes ; Histology ; Reprints ; Cadmium chloride ; Cadmium oxide
Library Call Number Additional Info Location Last
NTIS  PB89-109854 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 11p
The purpose of the study was to determine the toxicity of inhaled cadmium (Cd) on hepatic biochemical function. Male rats and rabbits were exposed for 2 hr to concentrations of 0.25, 0.45, and 4.5 mg Cd/cu m. Xenobiotic metabolizing enzymes, serum and liver enzymes, and histological changes were studied. Exposure to 4.5 mg/cu m CdCl2 and CdO resulted in an increase of liver Cd content in both rat and rabbit. Following exposure to 4.5 mg/cu m CdCl2, decreases in body and liver weight, and decreased activities of glutathione (GSH)-reductase, GSH-peroxidase, and glucose-6-phosphate dehydrogenase (G-6-PDH) were observed in rat liver. Exposure to a similar concentration of CdO caused decreased liver activities of GSH-reductase and peroxidase, G-6-PDH. The 0.45 mg/cu m exposure to CdCl2, collectively produced more hepatic effects in both rat and rabbit than did a similar exposure to CdO. The differential response was probably due to a more rapid clearance of CdCl2 or Cd+2 ions from the lung and transport to the liver via the systemic blood circulation as compared to CdO.