Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title miRNA Regulation of the Translational Machinery [electronic resource] /
Author Rhoads, Robert E.
Publisher Springer Berlin Heidelberg,
Year Published 2010
Call Number QD415-436
ISBN 9783642031038
Subjects Life sciences. ; Gene expression. ; Medicine. ; Biochemistry. ; Cytology.
Internet Access
Description Access URL
Collation X, 115p. 23 illus., 4 illus. in color. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression -- Translational Control of Endogenous MicroRNA Target Genes in -- Translational Inhibition by MicroRNAs in Plants -- Regulation of p27 mRNA Expression by MicroRNAs -- The Inhibitory Effect of Apolipoprotein B mRNA-Editing Enzyme Catalytic Polypeptide-Like 3G (APOBEC3G) and Its Family Members on the Activity of Cellular MicroRNAs -- MicroRNA-Mediated mRNA Deadenylation and Repression of Protein Synthesis in a Mammalian Cell-Free System -- miRNA Effects on mRNA Closed-Loop Formation During Translation Initiation. The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).