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OLS Field Name OLS Field Data
Main Title Acute Postnatal Exposure to Triethyltin in the Rat: Effects on Specific Protein Composition of Subcellular Fractions from Developing and Adult Brain.
Author O'Callaghan, James P. ; Miller, Diane B. ; Reiter, Lawrence W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-031;
Stock Number PB83-244202
Additional Subjects Brain ; Toxicology ; Exposure ; Rats ; Laboratory animals ; Protein ; Central nervous system ; Reprints ; Triethyltin
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-244202 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
Abstract
The morphological maturation of the central nervous system is characterized by onto-genetic changes in protein associated with specific developmental processes. In this investigation the authors examined the effects of acute postnatal administration of triethyltin (TET) on the ontogeny of proteins associated with myelinogenesis, synaptogenesis and synapitc junction formation. Myelin, synaptic plasma membrane and synaptosomal cytosolic franctions were prepared from 13-, 22-, and 66-day-old Long-Evans rats that had received either saline or TET (3.0 or 6.0 mg/kg i.p.) at 5 days of age. The specific protein composition of each franction was evaluated by resolution of the fraction proteins on sodium dodecyl sulfate-polyacrylamide slab gels.