||Acute Postnatal Exposure to Triethyltin in the Rat: Effects on Specific Protein Composition of Subcellular Fractions from Developing and Adult Brain.
O'Callaghan, James P. ;
Miller, Diane B. ;
Reiter, Lawrence W. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Central nervous system ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The morphological maturation of the central nervous system is characterized by onto-genetic changes in protein associated with specific developmental processes. In this investigation the authors examined the effects of acute postnatal administration of triethyltin (TET) on the ontogeny of proteins associated with myelinogenesis, synaptogenesis and synapitc junction formation. Myelin, synaptic plasma membrane and synaptosomal cytosolic franctions were prepared from 13-, 22-, and 66-day-old Long-Evans rats that had received either saline or TET (3.0 or 6.0 mg/kg i.p.) at 5 days of age. The specific protein composition of each franction was evaluated by resolution of the fraction proteins on sodium dodecyl sulfate-polyacrylamide slab gels.