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RECORD NUMBER: 30 OF 30

OLS Field Name OLS Field Data
Main Title Toxicity of Mercuric Chloride to the Developing Rat Kidney. 3. Distribution and Elimination of Mercury during Postnatal Maturation.
Author Daston, G. P. ; Rehnberg, B. F. ; Hall, L. L. ; Kavlock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/480;
Stock Number PB89-105456
Additional Subjects Toxicology ; Mercuric chloride ; Rats ; Kidneys ; Dosage ; Metabolism ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-105456 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 11p
Abstract
Mercuric chloride is a potent nephrotoxin in the adult rat, but has little effect on newborns. Nephrotoxicity increases with postnatal maturation. The study assesses the changes in tissue distribution and excretion of Hg during postnatal development. Sprague Dawley rats were injected so with 5 mg/kg (203)HgCl2 on postnatal day 1, 8, 15, 22 or 29. Hg concentration was measured in the whole body, renal cortex, medulla and papilla, liver, and subcellular fractions of liver and kidney. Binding to cytosolic metallothionein was assessed.