Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised).
Author Taubeneck, M. W. ; Daston, G. P. ; Rogers, J. M. ; Keen, C. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/400; NIH-HD01743;
Stock Number PB95-126447
Additional Subjects Zinc ; Metabolism ; Toxicity ; Rats ; Maternal exposure ; Nutrition ; Biological effects ; Maternal-fetal exchange ; Dose-response relationships ; Food consumption ; Statistical analysis ; Urethane ; Arsenic ; Alcohols ; Melphalan ; Metallothionein ; Reprints ; Alpha-hederin ; Acute phase response
Library Call Number Additional Info Location Last
NTIS  PB95-126447 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/06/1995
Collation 20p
The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development.