Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Carcinogenic Effects in A/J Mice of Particulate of a Coal Tar Paint Used in Potable Water Systems.
Author Robinson, M. ; Laurie, R. D. ; Bull, R. J. ; Stober, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Washington State Univ., Pullman. Coll. of Pharmacy.
Year Published 1987
Report Number EPA/600/J-87/008;
Stock Number PB87-180790
Additional Subjects Carcinogens ; Coal tar ; Paints ; Potable water ; Coatings ; Bioassay ; Adenoma ; Pulmonary neoplasms ; Mice ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB87-180790 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 8p
Coal tar paints are among the products used as inside coatings for water pipes and storage tanks to retard corrosion in potable water supply systems. Four different formulations of these paints were tested in earlier work by this laboratory in the Ames mutagenesis and the mouse skin carcinogenesis bioassays(6). The paint most active in these assays was then tested in a particulate form in the lung adenoma assay with A/J mice. The paint was applied to clean glass plates, cured, collected and homogenized in 2% Emulphor. Doses of this coal tar suspension were administered by gavage at 1.0, 10.0, and 55.0 mg in 0.2 ml per mouse 3 x weekly for 8 weeks. The total doses of coal tar paint were 24, 240, and 1320 mg/mouse. Benzo(a)pyrene, administered in a parallel schedule to a total dose of 6 mg/mouse, served as positive control. A negative control group received an equivalent volume of 2% Emulphor. Animals were sacrificed at 9 months of age (8 months after first dose) and lung adenomas counted. A dose-related response, in the average number of lung tumors per mouse, was observed with the coal tar particulate. There were also squamous cell tumors of the forestomach in 42% of the mice receiving 55.0 mg coal tar paint per application. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)