Record Display for the EPA National Library Catalog

RECORD NUMBER: 52 OF 312

OLS Field Name OLS Field Data
Main Title CASE-SAR (Computer Automated Structure Evaluation/Structure-Activity Relationship) Study of Mammalian Hepatic Azoreduction (Journal Version).
Author Nesnow, S. ; Bergman, H. ; Bryant, B. J. ; Helton, S. ; Richard, A. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA-68-02-4456; EPA/600/J-88/189;
Stock Number PB89-118806
Additional Subjects Azo dyes ; Carcinogens ; Toxicology ; Oxidoreductases ; Laboratory animals ; Predictions ; Computer programs ; Reprints ; Structure-activity relationship ; Liver microsomes
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-118806 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 16p
Abstract
A group of 36 aryl azo dyes were examined for their ability to be reduced by rat liver microsomal azoreductase. This group of azo dyes featured a variety of substituents including sulfonic acid, phenol, nitro, amide, and methyl functionalities on phenyl, alpha-naphthyl, and beta-naphthyl rings. Reduction rate constants for each dye were obtained using a spectrophotometric method and anaerobic incubation conditions. The reduction rate constants and dye structures provided the data for a CASE-SAR fragment analysis and three major structure fragments associated with the ability of this group of azo dyes to be reduced were identified. These structural fragments may be useful in future predictions of the ability of azo dyes to undergo reduction by rat liver azoreductase.