||Sensitivity, Specificity and Accuracy of the Arabidopsis Assay in the Identification of Carcinogens.
Redei, G. P. ;
Acedo, G. N. ;
Andhu, S. S. ;
||Missouri Univ.-Columbia.;Health Effects Research Lab., Research Triangle Park, NC.
In vitro analysis ;
In vivo analysis ;
Arabidopsis multilocus ;
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The paper compares the sensitivity, specificity and accuracy of Arabidopsis multilocus assay with several other in vitro and in vivo bioassays. Sensitivity was defined as a percentage of the carcinogens correctly identified as mutagens. Specificity was calculated by multiplying with 100 the fraction of the number correctly identified 'non-carcinogens'/total number of 'non-carcinogens' unambiguously classified. Accuracy represents the fraction of the correct answers/all unambiguous test, multiplied with 100. These parameters were estimated in Arabidopsis by testing 37 carcinogen/non-carcinogen pairs of chemicals. The overall sensitivity of Arabidopsis assay was higher than any of the bioassays employed in the Internation Collaborative Program.