Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 9

OLS Field Name OLS Field Data
Main Title Neurobehavioral Effects of Carbon Monoxide (CO) Exposure in Humans: Elevated Carboxyhemoglobin (COHb) and Cerebrovascular Responses.
Author Benignus, V. A. ; Petrovick, M. L. ; Prah, J. D. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC.
Publisher 19 May 89
Year Published 1989
Report Number 3E162777A878; CA;
Stock Number AD-A222 840/1
Additional Subjects Blood ; Blood circulation ; Brain ; Carbon monoxide ; Carboxylic acids ; Cerebrovascular system ; Commercial equipment ; Hemoglobin ; Humans ; Measurement ; Models ; Oxygen ; Reduction ; Response ; Toxicity ; Carboxyhemoglobin
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  AD-A222 840/1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/03/1990
Collation 58p
Abstract
A two-channel cranial impedance plethysmograph (CIP) was designed and constructed as a noninvasive measure of brain blood flow (BBF) in man. The instrument was designed to reduce some of the problems with instability and difficulty of use found in earlier commercially-available models. The CIP has been previously validated against other measures of BBF. During carboxyhemoglobin (COHb) formation, BBF is known to increase. When BBF increases it compensates for the reduced ability of the blood to carry oxygen in the presence of COHb. Fifteen men breathed carbon monoxide (CO) to produce increases in COHb values ranging from endogenous 18.4%. Keywords: Carbon monoxide, CO, Carboxyhemoglobin (COHb), Toxicity, Brain blood flow, Cerebrovascular. (JES)