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OLS Field Name OLS Field Data
Main Title Carboxyhemoglobin and Brain Blood Flow in Humans.
Author Benignus, V. A. ; Petrovick, M. K. ; Newlin-Clapp, L. ; Prah, J. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/314;
Stock Number PB92-227552
Additional Subjects Carboxyhemoglobin ; Brain ; Blood circulation ; Carbon monoxide ; Air pollution effects(Humans) ; Oxygen ; Exposure ; Toxicity ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Checkout
Status
NTIS  PB92-227552 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 8p
Abstract
It has been shown that with increased carboxyhemoglobin (COHb) and associated decrease in blood oxygen-carrying capacity, a compensatory increase in brain-blood flow (BBF) develops. The BBF response in humans has been shown to be quite variable. Two experiments were conducted in which humans were exposed to sufficient carbon monoxide (CO) to produce COHb levels up to 18.4%. BBF was measured by the method of impedance plethysmography. The first was a pilot study in which BBF in 14 men was studied after transient exposure to various concentrations of CO in air. BBF increased as a function of COHb, but not to the same extent (or at all) in some subjects. In a confirmatory experiment with 12 men, BBF was measured once per hr during a four-hr experiment. All 12 subjects received CO. The variation of the BBF response among subjects was large and statistically significant while the variation over time was not significant. Thus it appears that the magnitude of the BBF response is unique for a given subject and differs across subjects. These results may help predict CO-induced behavioral decrements in future studies if subjects whose BBF response to COHb is small or absent are also more susceptible to impairment by acute CO exposure. (Copyright (c) 1992 Pergamon Press Ltd.)