Main Title |
Effects of Low Dosage of Stable Strontium on Serum Enzymes in Chronic Alcoholics. |
Author |
Stara, J. F. ;
Perras, J. ;
Pivon, R. J. ;
Koch, P. ;
Nolan, J. T. ;
|
CORP Author |
Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;McGill Univ., Montreal (Quebec). ;La Maison Jean Lapointe, Montreal (Quebec). |
Publisher |
c1986 |
Year Published |
1986 |
Report Number |
EPA/600/D-89/032; |
Stock Number |
PB89-223911 |
Additional Subjects |
Strontium compounds ;
Alcoholism ;
Enzymes ;
Blood ;
Mitochondria ;
Dosage ;
Glucosephosphate dehydrogenase ;
Atomic absorption spectrophotometry ;
GGTP
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-223911 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
The study shows the systemic effects of low dosage of stable Sr(2+) in relation to chronic ethanol abuse. In the current study, 6 chronic alcoholic patients were administered Sr carbonate (600-700 mg of Sr(2+) per day) for periods of 4-6 weeks, alternating with treatment-free (placebo) intervals. Serum GDH was determined using Koch's modification; GGTP was determined using standard methodology (Gilford Stasar III). Serum ethanol levels were determined using Alcohol Dipstick Methodology of Kapur and Israel. Serum Sr(2+) and Ca(2+) levels were determined by Atomic Absorption Spectrophotometry. In patients receiving Sr(2+), serum GDH levels were decreased 61-68% (range 44.9-88.6%) when compared to the control periods during the acute alcoholic episodes. The effects of Sr(2+) on serum GGTP levels varied in extent of decrease. The preliminary studies indicate that low dosage of Sr(2+) exerts a protective effect on mitochondrial function during acute alcoholic episodes. |