B Cell Tolerance-How to Make It and How to Break It -- Breaking Ignorance: The Case of the Brain -- Naturally Arising Foxp3-Expressing CD25+CD4+ Regulatory T Cells in Self-Tolerance and Autoimmune Disease -- Sex Hormones and SLE: Influencing the Fate of Autoreactive B Cells -- Innate (Over)immunity and Adaptive Autoimmune Disease -- Can Unresolved Infection Precipitate Autoimmune Disease? -- The Systemic Autoinflammatory Diseases: Inborn Errors of the Innate Immune System -- Inefficient Clearance of Dying Cells and Autoreactivity -- The Importance of T Cell Interactions with Macrophages in Rheumatoid Cytokine Production -- T Cell Activation as Starter and Motor of Rheumatic Inflammation -- Signalling Pathways in B Cells: Implications for Autoimmunity -- Immunological Memory Stabilizing Autoreactivity -- Genetics of Autoimmune Diseases: A Multistep Process. (will follow)