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OLS Field Name OLS Field Data
Main Title Electrocardiographic Study of Cardiovascular Problems in Mirex-Fed Rat Fetuses.
Author Grabowski, Casimer T. ; Payne, Doris B. ;
CORP Author Miami Univ., Coral Gables, FL.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-R-805301-010; EPA-600/J-80-255;
Stock Number PB81-192015
Additional Subjects Electrocardiography ; Cardiovascular diseases ; Pesticides ; Toxicology ; Rats ; Females ; Embryos ; Reprints ; Fetuses ; Mirex
Holdings
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Status
NTIS  PB81-192015 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 13p
Abstract
Sperm-positive female rats were intubated with pesticide, Mirex, in oil (5 to 10 mg/kg) on days 8 1/2 to 15 1/2. Controls were untreated or oil-fed. Testing was done on day 18 1/2. Fetuses were sequentially exposed and ECGs obtained with fetus attached to the placenta and uterus. Counterparts of standard leads, I, II, and III were used. Fetuses were weighed and examined afterwards. Swollen fetuses were rated on a scale of 1 (slight edema under chin) to 5 (3mm edema across back). ECGs from 81 controls and 205 Mirex fetuses were obtained. They were evaluated for rate of heart beat, regularity of beat, PR intervals, and other features. One control exhibited an abnormality, a transitory period of premature atrial contractions. Mirex-fed fetuses frequently tachycardia, closedly correlated with degree of edema. The heart rate increased from 150/minute in controls to 180 in slightly swollen to 224 in swollen fetuses. Mean PR intervals increased with degree of swelling and with dose. The frequency of first degree heart-block was also dose-related, ranging from 20% in the 5 mg/kg group to 77% in the 10 mg/kg group. Second-degree heart-blocks were found in 8%, 3% showed arrhythmias and one had atrial flutter/fibrillation. These cardiovascular problems seem primarily related to the Mirex-induced edema and demonstrate that fetal edema is not innocuous. These data demonstrate the usefulness of fetal electrocardiography to detect functional teratology.