Record Display for the EPA National Library Catalog
RECORD NUMBER: 10 OF 10Main Title | Sulfamethoxazole-Trimethoprim Treatment of Guinea Pigs Infected with 'Legionella pneumpophila'. | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Author | Plouffe, J. F. ; Para, M. F. ; Bollin, G. E. ; | |||||||||||
CORP Author | Ohio State Univ., Columbus. Div. of Infectious Diseases.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Year Published | 1984 | |||||||||||
Report Number | EPA-R-812704; EPA/600/J-84/393; | |||||||||||
Stock Number | PB87-169181 | |||||||||||
Additional Subjects | Bacterial pneumonia ; Drug therapy ; Antibiotics ; Guinea pigs ; Laboratory animals ; In vivo analysis ; Reprints ; Legionnaires disease ; Legionella pneumophila ; Sulfamethoxazole-trimethoprim | |||||||||||
Holdings |
|
|||||||||||
Collation | 5p | |||||||||||
Abstract | Legionnaires' disease is a bacterial pneumonia caused by Legionella pneumophila. Many antibiotics inhibit the growth of L. pneumophila in vitro, but only erythromycin and rifampin have been clinically effective. Parallel results have been observed in guinea pigs infected ip with L. pneumophila. Antibiotics that were ineffective in this model include penicillin, tetracycline, chloramphenicol, gentamicin, and many cephalosporins. Using the guinea pig model, the authors studied the in vivo efficacy of sulfamethoxazole-trimethoprim. (Copyright (c) 1984 by the University of Chicago.) |