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RECORD NUMBER: 23 OF 27

OLS Field Name OLS Field Data
Main Title Relationship of Neuropathy Target Esterase Inhibition to Neuropathology and Ataxia in Hens Given Organophosphorus Esters.
Author Ehrich, M. ; Jortner, B. S. ; Padilla, S. ;
CORP Author Virginia-Maryland Regional Coll. of Veterinary Medicine, Blacksburg, VA.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher 1993
Year Published 1993
Report Number EPA-68-D8-0098; EPA/600/J-94/030;
Stock Number PB94-137247
Additional Subjects Esterases ; Enzyme inhibitors ; Toxicology ; Central nervous system ; Phosphorous organic compounds ; Ataxia ; Esters ; Pathology ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB94-137247 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/14/1994
Collation 7p
Abstract
Adult White Leghorn hens were acutely exposed to 3 dosages of the following organophosphorus compounds: mipafox, tri-ortho-tolyl phosphate (TOTP), phenyl saligenin phosphate, and diisopropylphosphorofluoridate (DFP). Neuropathy target esterase (NTE) activity was measured in brain and spinal cord 4 or 48 h after exposure. Ataxia was assessed using an 8-point rating scale on days 9 through 21 after administration, and neuropathological examination was conducted on samples collected from perfusion-fixed animals on day 21. Morphological alterations were indicated by lesion scores between 0 (no lesions) and 4 (diffuse involvement of spinal cord tracts and > 25% degeneration of peripheral nerve fibers). Dosages of mipafox, TOTP, phenyl saligenin phosphate, and DFP that were capable of inhibiting NTE > 80% in both brain and spinal cord preceded ataxia which reached maximal levels (scores of 7-8), and development of lesions scored as 4. Hens were notably impaired (ataxia scores of 3-4) 21 days after administration of dosages of mipafox, TOTP, phenyl saligenin phosphate, and DFP when spinal cord NTE was inhibited 40-75%. Lesions were, however, only noted in spinal cord and peripheral nerves of hens given TOTP or DFP (scores 1-3).