Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Relationship of Neuropathy Target Esterase Inhibition to Neuropathology and Ataxia in Hens Given Organophosphorus Esters.
Author Ehrich, M. ; Jortner, B. S. ; Padilla, S. ;
CORP Author Virginia-Maryland Regional Coll. of Veterinary Medicine, Blacksburg, VA.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher 1993
Year Published 1993
Report Number EPA-68-D8-0098; EPA/600/J-94/030;
Stock Number PB94-137247
Additional Subjects Esterases ; Enzyme inhibitors ; Toxicology ; Central nervous system ; Phosphorous organic compounds ; Ataxia ; Esters ; Pathology ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB94-137247 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/14/1994
Collation 7p
Adult White Leghorn hens were acutely exposed to 3 dosages of the following organophosphorus compounds: mipafox, tri-ortho-tolyl phosphate (TOTP), phenyl saligenin phosphate, and diisopropylphosphorofluoridate (DFP). Neuropathy target esterase (NTE) activity was measured in brain and spinal cord 4 or 48 h after exposure. Ataxia was assessed using an 8-point rating scale on days 9 through 21 after administration, and neuropathological examination was conducted on samples collected from perfusion-fixed animals on day 21. Morphological alterations were indicated by lesion scores between 0 (no lesions) and 4 (diffuse involvement of spinal cord tracts and > 25% degeneration of peripheral nerve fibers). Dosages of mipafox, TOTP, phenyl saligenin phosphate, and DFP that were capable of inhibiting NTE > 80% in both brain and spinal cord preceded ataxia which reached maximal levels (scores of 7-8), and development of lesions scored as 4. Hens were notably impaired (ataxia scores of 3-4) 21 days after administration of dosages of mipafox, TOTP, phenyl saligenin phosphate, and DFP when spinal cord NTE was inhibited 40-75%. Lesions were, however, only noted in spinal cord and peripheral nerves of hens given TOTP or DFP (scores 1-3).