Record Display for the EPA National Library Catalog

RECORD NUMBER: 9 OF 25

OLS Field Name OLS Field Data
Main Title Inhibitation of Benzo(A)Pyrene Monooxygenase by alpha-Naphthoflavone may be Partially Mediated by the Metabolite 9-Hydroxy-alpha-Naphthoflavone.
Author Nesnow, Stephen ; Easterling, Robert ; Bergman, Hinda ; Roth, Robert ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-153;
Stock Number PB83-189654
Additional Subjects Inhibitors ; Rats ; Liver ; Microsomes ; Metabolism ; Reprints ; Metabolites ; Benzopyrene monooxygenase ; Naphthoflavone ; Naphthoflavone/hydroxy
Holdings
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Status
NTIS  PB83-189654 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 10p
Abstract
Naphthoflavone (ANF) inhibits beta-naphthoflavon-induced rat liver microsomal benzo(a)pyrene metabolism and is transformed by these microsomes into naphthoflavone metabolites. The authors determined the inhibitory effect on benzo(a)pyrene (B(a)P) metabolism of several of these metabolites and of 6-methoxy-ANF, using beta-naphthoflavone-induced rat liver microsomes. 9-Hydroxy-ANF was the most active inhibitor (I50 = 1.47 micro M) and was metabolized from ANF by these hepatic cimrosomes in concentrations which are inhibitory. Therefore, 9-hydroxy-ANF a microsomal metabolite of ANF, may play a role in the inhibition of B(a)P oxidation by ANF.