Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 25

OLS Field Name OLS Field Data
Main Title Identification of Cocarcinogens and Their Potential Mechanisms of Action Using C3H10T(1/2)CL8 Mouse Embryo Fibroblasts.
Author Nesnow, Stephen ; Leavitt, Sharon ; Garland, Helen ; Vaughan, T. Owens ; Hyatt, Betty ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-202;
Stock Number PB82-247206
Additional Subjects Carcinogens ; Toxicology ; Identifying ; Mice ; Reprints ; Fibroblasts ; Fetuses
Holdings
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Status
NTIS  PB82-247206 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
The cocarcinogenic action of five agents which increase microsomal mixed-function oxidase activity in vivo was examined in the C3H101/2CL8 transformation assay. The compounds studies were benz(a)anthracene, 5,6-benzoflavone, phenobarbital, pregnenolone-16a-carbon-nitrile, and Aroclor 1254. After a 48-hr pretreatment with the agent, the cells were then treated with benzo(a)pyrene (B(a)P) and the agent for an additional 24hr. This suggests that these agents exert their cocarcinogenic action via increases in the enzyme-mediated pathways of B(a)P metabolism.