Record Display for the EPA National Library Catalog

RECORD NUMBER: 11 OF 25

OLS Field Name OLS Field Data
Main Title Inhibition of Microsomal Metabolism and Chemical Oncogenesis in Culture by Naphthalene Quinones.
Author Nesnow, Stephen ; Bergman, Hinda ; Garland, Helen ; Morris, Mary ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-600/J-79-149;
Stock Number PB83-145284
Additional Subjects Ribosomes ; Inhibition ; Metabolism ; Liver ; Rats ; Reprints ; Oncogenesis ; Naphthalene quinones
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-145284 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 16p
Abstract
A series of napthalene diols, quinones, and related compounds were examined for their ability to inhibit mixed-function oxidase activities in liver microsomes obtained from rats which had been pretreated with 3-methylcholanthrene (3-MC) or phenobarbital (PB). Using benzo(a)pyrene monooxygenase as a measure of mixed-function oxidase activity, it was found that phenanthrene-9,10-quinone was the most active compound tested with a K1=0.79 uM.