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RECORD NUMBER: 17 OF 24

OLS Field Name OLS Field Data
Main Title Investigations of Amitraz Neurotoxicity in Rats. 4. Assessment of Toxicity Syndrome Using a Functional Observational Battery.
Author Moser., V. C. ;
CORP Author NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/J-91/182;
Stock Number PB91-233452
Additional Subjects Toxicity ; Nervous system ; Pesticides ; Rats ; Animal behavior ; Body weight ; Dose-response relationships ; Light ; Body temperature ; Reprints ; Amitraz
Holdings
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Status
NTIS  PB91-233452 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/26/1991
Collation 12p
Abstract
A functional observational battery (FOB) was utilized to provide a semiquantitative description of the hyperractivity, excitability, and debilitation produced by amitraz. Adult male Long-Evans rats were administered either vehicle or 10, 25, 50, 100, or 200 mg/kg amitraz ip. They were tested with the FOB immediately before dosing, at 1 and 4 hr, and at 1, 2, 4, and 8 days after dosing. Higher doses (100-200 mg/kg) produced increased reactivity to manipulation, tenseness, and aggression. Most or all doses produced depressed arousal and rearing activity, hypothermia, body weight loss, and autonomic changes including ptosis, chromodacryorrhea resulting in facial crustiness, loss of the pupil reflex, and decreased defecation. Altered gait and decreased landing foot splay were also produced by amitraz. For the most part, effects of lower doses (10-50 mg/kg) were reversible by 2 to 4 days after treatment. In the higher dose groiups, however, signs of toxicity were evident, and in some cases even more prominent (e.g., handling hyperreactivity), 8 days after a single dose of amitraz. The FOB thus provided a semiquantitative description of the magnitude and time course of many features of the amitraz toxicity syndrome. (Copyright (c) 1991 by the Society of Toxicology, All rights of reproduction in any form reserved.)