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RECORD NUMBER: 2 OF 24

OLS Field Name OLS Field Data
Main Title Applications of a Neurobehavioral Screening Battery.
Author Moser., V. C. ;
CORP Author NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/J-92/152;
Stock Number PB92-179787
Additional Subjects Nervous system ; Toxicology ; Toxic substances ; Behavior ; Rats ; Dose-response relationships ; Physiology ; Reprints ; Neurobehavioral test battery
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-179787 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/22/1992
Collation 11p
Abstract
With the growing awareness of the neurological effects of many environmental chemicals, there is considerable emphasis being placed on the detection of neurotoxic potential at the screening, or first-tier, level of testing. The authors have developed a neurobehavioral screening battery consisting of a functional observational battery (FOB) and an automated measure of motor activity which can be incorporated into neuropathological studies as well as general toxicity assessments of new and existing chemicals in rats. This approach has been recommended by several expert national and international panels, and has recently been recommended by the US Environmental Protection Agency for testing pesticides and industrial chemicals. The FOB consists of a series of home-cage, open-field, and interactive assessments of the rat's behavior and neurological functions. Motor activity provides an objective apical measure of the rat's neurobehavioral function. In order to assess validity, sensitivity, and specificity, the authors have utilized these test methods to determine dose-response and time-course characteristics of a wide variety of chemicals including pesticides, metals, solvents, and industrial compounds.