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RECORD NUMBER: 13 OF 24

OLS Field Name OLS Field Data
Main Title International Validation of a Neurobehavioral Screening Battery: The IPCS/WHO Collaborative Study.
Author Moser, V. S. ; MacPhail, R. C. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/J-93/090;
Stock Number PB93-175594
Additional Subjects Toxic substances ; Nervous system ; Behavior ; Interlaboratory comparisons ; Exposure ; Dose-response relationships ; Reprints ; Functional observational battery
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-175594 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/23/1993
Collation 8p
Abstract
A neurobehavioral screening battery consisting of a functional observational battery (FOB) and an automated measure of motor activity is the subject of an international collaborative study. Eight laboratories (four in Europe, four in the U.S.) are participating in the study, which is sponsored by the International Programme on Chemical Safety within the World Health Organization. Representatives from each laboratory received training on testing procedures and the study protocol during a 2-day workshop. Each laboratory then conducted studies using positive control chemicals to demonstrate their proficiency with the techniques. For motor activity studies, each laboratory had to show acute increases and decreases in activity produced by triadimefon and chlorpromazine, respectively. Using the FOB, each laboratory had to detect certain neurological syndromes: tremorigenic activity of a single dose of p,p'-DDT, cholinergic signs with parathion, and neuromuscular deficits with short-term (1-2 weeks) repeated administration of acrylamide. In the formal studies, the effects of seven chemicals are currently being determined following both acute and 4-week exposures. The chemicals include triethyl tin, acrylamide, parathion, p,p'-DDT, toluene, lead acetate, and N,N'-methylene bisacrylamide. Each laboratory also determines a maximum-tolerated dose for each compound as well as the time of peak effect following acute exposure.