EPA Research Pathfinder Innovation Projects (PIPs), an internal competition for Agency scientists, was launched in 2010 to solicit innovative research proposals that would help the Agency to advance science for sustainability. In 2011, of the 117 proposals received from almost 300 scientists, 12 winners were awarded with seed funding to pursue their creative solutions to environmental and human health challenges. One of these projects was Systems Reality Modeling Project, Step 1: Chemical Inventory. A team of nine scientists from the National Exposure Research Laboratory (NERL) and the National Center for Environmental Assessment (NCEA) (eight from NERL, one from NCEA) proposed to develop novel informatics and data curation approaches that both exposure assessment communities and proactive members of the public may use to become more aware of the chemicals present in our living space and lifestyle. This awareness is a component of personal chemical exposure informatics. A two-day workshop on Personal Chemical Exposure Informatics was held on June 26 and 27, 2012, at the US Environmental Protection Agency campus in Research Triangle Park, North Carolina. This report details the presentations and breakout group discussions to further advance this particular research field and identify gaps for additional efforts.