||In Vitro and In Vivo mutagenicity studies of environmental chemicals /
Jones, D. C. L. ;
Simmon, V. F. ;
Mortelmans, K. E. ;
Mitchell, A. D. ;
Evans, E. L.
||SRI International, Menlo Park, CA.;Health Effects Research Lab., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Pesticides and wildlife--United States. ;
In vitro analysis ;
In vivo analysis ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||583 pages ; 28 cm
The objectives of this project were to evaluate the mutagenicity of various compounds, mostly pesticides, using microbial and mammalian cell in vitro techniques, as well as in vivo techniques in Drosophila and mice, and to further develop and refine these procedures for application as test batteries. Seventy-nine compounds were evaluated for mutagenicity in one or more of 11 test systems: Salmonella typhimurium plate incorporation assay; E. coli WP-2 reverse mutation assay; S. cerevisiae D3 mitotic recombination assay; Saccharomyces cerevisiae D7 assays; Escherichia Coli, Bacillus subtilis, and S. typhimurium relative toxicity assays; siter-chromatid exchange in Chinese hamster ovary cells assay; L5178Y mouse lymphoma cell forward mutation assay; unscheduled DNA synthesis assay; mouse micronucleus assay; Drosophila sex-linked recessive lethal assay; and mouse dominant lethal assay. The data from the evaluation of 41 pesticides and 10 industrial chemicals are presented in this report. Qualitative interpretations of these data and of data obtained under a previous contract, including those for an additional 28 pesticides, are summarized.
Distributed to depository libraries in microfiche. "January 1984." Includes bibliographical references. "EPA-600/1-84-003." Microfiche.