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RECORD NUMBER: 17 OF 39

OLS Field Name OLS Field Data
Main Title Effects of 3,4-Methylenedioxymethamphetamine on Autonomic Thermoreregulatory Responses of the Rat.
Author Gordon, C. J. ; Watkinson, W. P. ; O'Callaghan, J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/021;
Stock Number PB91-183459
Additional Subjects Toxicology ; Body temperature regulation ; Autonomic nervous system ; Rats ; Vasoconstriction ; Hypothermia ; Hyperthermia ; Sodium chloride ; Motor activity ; Heart rate ; Metabolism ; Reprints ; Methylenedioxyamphetamines
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB91-183459 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 8p
Abstract
3,4-methylenedioxymethamphetamine (MDMA), a substituted amphetamine analogue which stimulates serotonin release in the CNS, has been shown to induce near lethal elevations in core temperature in the rat. To characterize the effects of MDMA on temperature regulation, the study measured metabolic rate (MR), evaporative water loss (EWL), motor activity (MA), and colonic temperature (Tc) in male, Long-Evans rats at 60 min following 30 mg/kg (s.c.) MDMA or saline at ambient temperatures (Ta) of 10, 20, and 30C. MDMA caused an elevation in MR at Ta's of 20 and 30C but had no effect at 10C. At a Ta of 30C, MR of the MDMA group was double that of the saline group. EWL was elevated by MDMA, an effect which was potentiated with increasing Ta. MDMA also elicited an increase in MA at all three Ta's. MDMA led to a 3.2C increase in Tc at 30C, no change in Tc at 20C, and a 2.0C decrease in Tc at 10C. The data suggest that, at relatively warm Ta's, MDMA-induced stimulation of serotonergic pathways causes an elevation in MR and peripheral vasoconstriction, thus producing life-threatening elevations in Tc. The increase in EWL following MDMA partially attenuates the hyperthermia at warm Ta's and leads to hypothermia in the rat maintained at a cold Ta of 10C.